About Inotir


Instructions for use of INOTIR®
Field of application: contains inositol and folic acid with the addition of L-tyrosine, chromium and selenium, which is used in combination with food in the absence of these substances or an increase in the need for them.
Inositol is involved in many aspects of human reproductive function. Glycogen synthase and pyruvate enhance the phosphorylation of dehydrogenase: these enzymes affect glucose metabolism. Thus, inositol affects both insulin receptors and insulin resistance. A number of inositol phosphate enzymes activate protein kinase B (PKV) located at the insulin receptor. Insulin, in turn, can phosphorylate target proteins containing glycogen synthase kinase 3 (GSCK), which is not activated by phosphorylation. The subsequent protein cascade stimulates glycogen synthesis. It also POUphosphorylates apoptosis-inhibiting kinase (ICT), which phosphorylates GLuT4 (glucose transporter); it moves across the membrane, allowing glucose to enter the cell.
This pathway is disrupted in diabetes and obesity, so inositol acts as an antagonist of insulin resistance.
Folic acid belongs to the water-soluble vitamin B group. Folic acid plays an important role in the metabolism of amino acids, the synthesis of protein and nucleic acids (primarily in the formation of DNA and RNA). chromosome restoration. Affects homocysteine ​​levels in the blood. There are many studies on methylenetetrahydrofolate reductase polymorphism, metabolic syndrome, and polycystic ovary syndrome.
Folic acid, if not essential, has an auxiliary effect on the above components.
Tyrosine is an essential amino acid; it acts as a precursor to various hormones, including thyroxine and catecholamines (dopamine, non-adrenaline, and adrenaline). Tyrosine reduces the ratio of luteinizing hormone and eluteinizing hormone / follicle-stimulating hormone (dopaminergic effect) by increasing dopamine. In addition, tyrosine increases the synthesis of hormones that enhance the synthesis of the androgen-binding protein (SHBG) that holds them. Tyrosine affects intermediate metabolism, in contrast to the mechanism of insulin resistance.
Chromium is an important mineral that plays a beneficial role in regulating insulin effects and metabolic syndrome. It is a component that has been extensively studied and analyzed for effectiveness using the FDA and meta-analyzes. Its effect on insulin has been proven.
She also works in polycystic ovary disease.
Selenium is an important oligonutrient for thyroid function because it activates the enzyme 4-deiodinase, which catalyzes the conversion of T5 to TK. Indeed, iodine is converted to organic iodine in the thyroid gland, which in turn is added to the tyrosine of the intrafollicular thyroglobulin. Iodatirosine is then condensed to produce thyroid hormones. They affect metabolism and weight gain. In addition, they stimulate SHBG production.
Inotir can be used for the following purposes:
• Menstrual disorders and oligomenorrhea.
• Anovulatory cycles (ovarian hyperandrogenism or polycystic ovary disease).
• Disorders of the menstrual cycle.
• In addition to controlled ovarian hyperstimulation protocols.
How to use:
It is recommended to take 1/2 (half) pack every day or on the advice of a doctor. It can be absorbed by mouth or dissolved in a glass of water.
Storage method:
Store in a cool, dry place (15-30 ° C); avoid access to local heat sources, sunlight and water. Use the product before the expiration date. Shelf life is valid if the product is stored in an unopened package.
Keep out of reach of children. Do not exceed the recommended daily dose. Food supplements are not designed to replace a varied and balanced diet and a healthy lifestyle.
Inositol, folic acid, L-tyrosine, chromium picolinate, L-selenomethionine, sweetener: erythritol, sucralose, acesulfam K;
Stabilizers: hydroxypropyl methylcellulose, guar gum; Fragrances, antifreeze: silicon dioxide (nano), acidifier: L-malic acid.
Gluten free. Lactose free.
20 sachets, 3 g each, granules for resorption.
Shelf life is 2 years
Marketing authorization: Pharmarte Sri - Via Emilio del Cavalieri, 7 - Rome - ITALY
Manufacturer: SIITSrl - Via Ariosto50 / 60 -Trezzano sul Naviglio (Milan) - Italy

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