To the Presidential Decree "On measures to expand and further improve the system of training highly qualified personnel in Surkhandarya region." (No. PQ-4681, 17.04.2020) Accordingly, the Denau Institute of Entrepreneurship and Pedagogy of Samarkand State University was established on the basis of the Denau branch of Termez State University.

The educational activity of the institute started from the 2020-2021 academic year.