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💉 Amikasin injection
📜 Basic information about the drug
Contents:
1 vial contains:
💧 active substance: amikacin sulfate (recalculated to amikacin) - 500 mg.
⁉️ Description: white or almost white powder, hygroscopic.
📝 Trade name of the drug:
Amikacin
🧬 Pharmacological group:
antibiotic (group of aminoglycosides)
💉 Dosage form:
powder to prepare a solution for intravenous and intramuscular administration
👉 Mechanism of action:
Semi-synthetic antibiotic with a wide range of action, has a bactericidal effect.
It binds to 30S subunits of ribosomes, inhibits the formation of transport and matrix RNA complexes, blocks protein synthesis, and disrupts the titoplasmic membranes of bacteria.
Aerobic gram-negative microorganisms - Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Serratia spp., Providencia spp., Enterobacter spp., Salmonella spp., Shigella spp .; to some gram-negative microorganisms - Staphylococcus spp.
relatively resistant (including penicillin, resistant to some tefalasporins); Streptococcus spp.
moderately active relative to.
When administered concomitantly with benzylpenicillin, it has a synergistic effect against strains of Enterococcus faecalis.
Does not affect anaerobic microorganisms.
Amikacin does not lose its activity under the influence of enzymes that inactivate other aminoglycosides, and may retain its activity against strains of Pseudomonas aeruginosa resistant to tobramycin, gentamicin and netilmycin.undefined
🔥 Application:
Infectious and inflammatory diseases caused by gram-negative microorganisms (resistant to gentamicin, sizomycin and kanamycin) or by the association of gram-positive and gram-negative microorganisms: respiratory infections (bronchitis, pneumonia, pleural empyema, pulmonary abscess), sepsis, septic endocarditis systemic (MNT) infections (including meningitis), abdominal infections (including peritonitis), urinary tract infections (pyelonephritis, cystitis, urethritis), purulent infections of the skin and soft tissues (including) , infected burns, infected wounds and bed sores of various genesis), biliary tract, bone and joint infections (including osteomyelitis), wound infections, postoperative infections…